雷公藤可作为治疗肥胖的潜在药物

An extract from the thunder god vine, which has a long history of use in traditional Chinese medicine, reduces food intake¹ and causes up to a 45% decrease in body weight in obese² mice. The weight-loss compound, called Celastrol, produces its potent³ effects by enhancing the action of an appetite-suppressing hormone⁴ called leptin. The findings, published May 21 in Cell, are an early indicator⁵ that Celastrol could be developed into a drug for the treatment of obesity⁶. "During the last two decades, there has been an enormous amount of effort to treat obesity by breaking down leptin resistance, but these efforts have failed," says senior study author Umut Ozcan, an endocrinologist atBoston Children's Hospital and Harvard Medical School. "The message from this study is that there is still hope for making leptin work, and there is still hope for treating obesity. If Celastrol works in humans as it does in mice, it could be a powerful way to treat obesity and improve the health of many patients suffering from obesity and associated complications, such as heart disease, fatty liver, and type 2 diabetes⁷."   Leptin is a fat-cell-derived hormone that signals to the brain when the body has enough fuel and energy. Humans and mice that lack leptin signaling eat voraciously⁸ and become morbidly⁹ obese, suggesting that leptin-enhancing drugs may be effective for treating obesity. But leptin does not reduce hunger or food intake in obese individuals despite high levels of the hormone in the bloodstream, leading many researchers to speculate that leptin insensitivity is the root cause of obesity. Despite longstanding research efforts, drugs that can effectively alleviate¹⁰ leptin resistance have not yet been found. However, one potential clue to this problem came several years ago when Ozcan and his team discovered that leptin resistance is associated with a stress response in a cell structure called the endoplasmic reticulum (ER).