乐观似乎取决于基因

FOR some people in this world, the glass always seems to be half-full. For others it is half-empty. But how someone comes to have a sunny disposition¹ in the first place is an interesting question.   It has been known for a long time that optimists² see the world selectively, mentally processing positive things while ignoring negative ones, and that this outlook helps determine their health and well-being³. In recent years, it has also become clear that carriers of a particular version of a particular gene⁴ are at higher risk than others of depression and attempted suicide when they face traumatic events. The gene in question lies in a region of the genome that promotes the activity of a second gene, which encodes a protein called the serotonin transporter. Serotonin is a messenger molecule⁵ that carries signals between nerve cells, and it is known to modulate⁶ many aspects of human behaviour, although the details are complex and controversial. The transporter protein recycles serotonin back into the cell that produced it, making it available for reuse, but also reducing the amount in the junctions⁷ between cells and thus, it is presumed, the strength of the signal.   It has looked increasingly likely, therefore, that genes⁸ -- particularly those connected with serotonin -- have a role to play in shaping a person's outlook. So Elaine Fox and her colleagues at the University of Essex, in Britain, wondered whether genes play a part in the selective attention to positive or negative material, with consequent effects on outlook.   To find out, they took samples of DNA⁹ from about 100 people and then subjected these people to what is known as the dot-probe paradigm¹⁰ test to see how they reacted to different stimuli¹¹. In this test participants are briefly¹² shown photographs that may be positive, negative or neutral in tone. They then have to press a keypad to indicate when a dot has appeared on the screen. It has been found by experience that the more distracting an image is, the longer a person takes to respond when the dot appears. That allowed Dr Fox and her team to discover how distracting particular people found particular images.   In a paper just published in the Proceedings¹³ of the Royal Society B they report that, sure enough, gene-related variation caused a bias¹⁴ in attention towards positive and negative material. Some people had two "long" versions of the promoter gene (one inherited from each parent), a combination that reduces the amount of serotonin in the junctions between nerve cells. These individuals were biased#p#分页标题#e#¹⁵ towards positive images and away from negative ones. By contrast, those who had either a long and a short version of the gene, or two short versions (and thus, presumably, more serotonin in the junctions), did not have such protective biases¹⁶. In other words, the optimists really did see the world differently.   Rose-tinted spectacles may be good for one's health, as these results fit in with wider ideas about how a tendency to look on the bright side of life is part of being resilient to stress. Those with short variants¹⁷ of this gene are expected to have an increased susceptibility to mood disorders¹⁸ following such stress. It is not all good news, though, for optimists. Because these results suggest that a person's attitude to life is inherited, they serve as a stark¹⁹ warning to all buoyant optimists that trying to cheer the rest of the world up with nothing more than a smile and an effortlessly sunny disposition is doomed²⁰ to failure.