有更好“性生活”的果蝇寿命更长

Sex may in fact be one of the secrets to good health, youth and a longer life -- at least for fruit flies -- suggests a new University of Michigan study that appears in the journal Science. Male fruit flies that perceived（感知，领会） sexual pheromones of their female counterparts -- without the opportunity to mate -- experienced rapid decreases in fat stores, resistance to starvation and more stress. The sexually frustrated¹ flies lived shorter lives.   Mating, on the other hand, partially² reversed the negative effects on health and aging.   "Our findings give us a better understanding about how sensory³ perception and physiological⁴ state are integrated in the brain to affect long-term health and lifespan," says senior author Scott D. Pletcher, Ph.D, professor in the Department of Molecular⁵ and Integrative Physiology⁶ at the U-M Medical School and research professor at the U-M Geriatrics Center.   "The cutting-edge genetics and neurobiology used in this research suggests to us that for fruit flies at least, it may not be a myth that sexual frustration⁷ is a health issue. Expecting sex without any sexual reward was detrimental⁸（有害的） to their health and cut their lives short."   U-M scientists used sensory manipulations to give the common male fruit fly, Drosophila melanogaster, the perception that they were in a sexually rich environment by exposing them to genetically⁹ engineered males that produced female pheromones. They were also able to manipulate the specific neurons responsible for pheromone perception as well as parts of the brain linked to sexual reward (secreting a group of compounds associated with anxiety and sex drive).   "These data may provide the first direct evidence that aging and physiology are influenced by how the brain processes expectations and rewards," Pletcher says. "In this case, sexual rewards specifically promoted healthy aging."   Fruit flies have been a powerful tool for studying aging because they live on average 60 days yet many of the discoveries in flies have proven effective in longer-lived animals, such as mice.   For decades, one of the most powerful ways to slow aging in different species was by limiting their food intake¹⁰. In a previous study, Pletcher and his colleagues found that the smell of food alone was enough to speed up aging, offering new context for how dietary restriction¹¹ works.