细菌使我们感到饥饿？

Over the last half decade, it has become increasingly clear that the normal gastrointestinal（胃肠的） (GI) bacteria play a variety of very important roles in the biology of human and animals. Now Vic Norris of the University of Rouen, France, and coauthors propose yet another role for GI bacteria: that they exert some control over their hosts' appetites. Their review was published online ahead of print in the Journal of Bacteriology. This hypothesis is based in large part on observations of the number of roles bacteria are already known to play in host biology, as well as their relationship to the host system. "Bacteria both recognize and synthesize neuroendocrine hormones," Norris et al. write. "This has led to the hypothesis that microbes within the gut¹ comprise a community that forms a microbial organ interfacing² with the mammalian nervous system that innervates the gastrointestinal tract³." (That nervous system innervating the GI tract is called the "enteric nervous system." It contains roughly half a billion neurons, compared with 85 billion neurons in the central nervous system.)   "The gut microbiota respond both to both the nutrients⁴ consumed by their hosts and to the state of their hosts as signaled by various hormones," write Norris et al. That communication presumably goes both ways: they also generate compounds that are used for signaling within the human system, "including neurotransmitters such as GABA, amino acids such as tyrosine and tryptophan -- which can be converted into the mood-determining molecules⁵, dopamine（多巴胺） and serotonin（血清素）" -- and much else, says Norris.   Furthermore, it is becoming increasingly clear that gut bacteria may play a role in diseases such as cancer, metabolic⁶（新陈代谢的） syndrome⁷, and thyroid disease, through their influence on host signaling pathways. They may even influence mood disorders⁸, according to recent, pioneering studies, via actions on dopamine and peptides involved in appetite. The gut bacterium⁹, Campilobacter jejuni, has been implicated¹⁰ in the induction¹¹ of anxiety in mice, says Norris.   But do the gut flora¹² in fact use their abilities to influence choice of food? The investigators¹³ propose a variety of experiments that could help answer this question, including epidemiological（流行病学） studies, and "experiments correlating the presence of particular bacterial¹⁴ metabolites with images of the activity of regions of the brain associated with appetite and pleasure."#p#分页标题#e#