老年痴呆症的早期预警系统

Scientists at the University of Strathclyde in Glasgow are developing a technique based on a new discovery which could pave the way towards detecting Alzheimer's disease in its earliest stages - and could help to develop urgently-needed treatments. The technique uses the ratio of detected fluorescence（荧光） signals to indicate that clusters of peptide（缩氨酸） associated with the disease are beginning to gather and to have an impact on the brain. #

Current techniques are not able to see the peptide joining together until more advanced stages but a research paper from Strathclyde describes an approach which could not only give indications of the condition far sooner than is currently possible but could also screen patients without the need for needles or wires. #

Alzheimer's disease, the most common form of dementia, currently affects around 450,000 people in the UK alone and currently has no cure. #

Dr Olaf Rolinski, of the University of Strathclyde's Department of Physics, led the research. He said: "Alzheimer's Disease has a devastating¹ impact on people around the world and their families but one of the reasons it is still incurable² is that little is known about how and why the peptide that contributes to the disease aggregates³（聚集，共计） in its initial stages.

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"When irradiated with light, the intrinsic（本质的，固有的） fluorescence given off by the peptide is like a communication from a spy. We took samples of the peptide and discovered that, where they were in the type of aggregation⁴ linked to Alzheimer's, they produced fluorescence light signals which could be picked up with our technique much earlier than in more conventional experiments, such as those that use the addition of a dye（染料，染色） .

"This approach could help us understand better the role of these peptides in the onset⁵ of Alzheimer's and discover ways in which the disease could be stopped in its tracks early on. We now want to take the research further so that it can be used in the development of drugs to treat Alzheimer's." #