脑部乳酸含量可揭示衰老情况

Researchers at the Swedish medical university Karolinska Institutet have shown that they may be able to monitor the aging process in the brain, by using MRI technique to measure the brain lactic¹ acid（乳酸） levels. Their findings suggest that the lactate levels increase in advance of other aging symptoms, and therefore could be used as an indicator² of aging and age-related diseases of the CNS. "It's exciting to think that we are one step closer to understanding what happens as the brain ages, and how a change of brain metabolism³（新陈代谢） may be important during the onset⁴ of age-related changes and diseases", says Professor Lars Olson, who lead the study. #

The research group used both prematurely⁵ and normally aging mice to investigate the relationship between damage to mitochondria（线粒体） — the organelle（细胞器） responsible for energy production in the cell — and changes in metabolism during the aging process. Previous studies have shown a link between mitochondrial dysfunction and age-related neurodegenerative（神经变性的） disorders⁶, such as Parkinson's and Alzheimer´s disease. #

In the current study, which is published in the Proceedings⁷ of the National Academy of Sciences, the researchers show that the damage to the mitochondria slowly increases with age in brains of mice and causes altered expression in certain genes⁸ that are responsible for the formation of lactate. They also show that brain lactate levels may increase in advance of other indices（指数，目录） of aging, and can be detected using non-invasive magnetic resonance⁹ imaging techniques. #

"Our study was conducted in mice, but the same technique can be used in humans", says Lars Olson. "So there is hope that one day physicians might be able to give your brain a check-up and help determine its age by using MRI."