人造化学酶可中和自然毒素

For the first time ever, a completely man-made chemical enzyme¹（酶） has been successfully used to neutralise（中和，使无效） a toxin² found naturally in fruits and vegetables. While studying for her PhD in chemistry at the University of Copenhagen Dr. Jeannette Bjerre showed how a novel so-called chemzyme was able to decompose³（分解，腐烂） glycoside（配糖） esculin（七叶灵） , a toxin found in horse-chestnuts（栗子） .

Proof of concept for artificial enzymes⁴ #

Chemzymes are designed molecules⁵ emulating⁶（仿效） the targeting and efficiency of naturally occurring enzymes and the recently graduated Dr. Bjerre is pleased about her results. #

"Showing that these molecules are capable of decomposing⁷ toxins⁸ required vast amounts of work and time. But it's been worth every minute because it proves the general point that it's possible to design artificial enzymes for this class of task", explains Bjerre.

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Simple molecules performing complex tasks

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Most people know enzymes as an ingredient（原料，要素） in detergents⁹（洗涤剂） . In our bodies enzymes are in charge of decomposing everything we eat, so that our bodies can absorb the nutrients¹⁰. But they also decompose ingested toxins, ensuring that our bodies survive the encounter.

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In several important aspects artificial enzymes function in the same way as naturally occurring ones. But where natural enzymes are big and complex, the artificial ones have been pared down（减少，削减） to the basics. #

The flat-nosed plier of the molecular¹¹ world #

One consequence of this is that designing chemzymes for targeted tasks ought to be easier. With fewer parts, there's less to go wrong when changing the structure of chemzymes. And for enzymes as well as for their artificial counterparts even small changes in structure will have massive consequences for functionality. #

In this, enzymes are very much like hand-tools, where scissors and flat nosed pliers（钳子） , though almost identical, have very different duties.

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Hardwearing replacement¹² enzymes #

Even though naturally occurring enzymes are several orders of magnitude smaller than flat-nosed pliers, they are still unrivalled（无与伦比的，无敌的） tools. Some of the fastest chemical reactions blast off when enzymes are added to the broth¹³（肉汤，液体培养基） . #

Several known enzymes in the body catalyze¹⁴ more than one million reactions per second when they decompose compounds. There's just one drawback to enzymes. They are extremely fragile.#p#分页标题#e# #

If an enzyme in our body was to be warmed above sixtyfive degrees centigrade or subjected to organic solvents¹⁵（溶剂） , they would immediately denature. They would unravel¹⁶ and stop functioning. #

Taking the heat

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So far no one has succeeded in designing chemzymes that are anywhere near as fast as their naturally occurring cousins. But they are far more resilient. Manmade enzymes take on heat and solvents without batting a molecular eyelid¹⁷. One of the consequences of this is that chemzymes can be mass-produced using industrial chemical processes. This is a huge advantage when you need a lot of product in a hurry.

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Factory-made enzymes

Producing natural enzymes in industrial settings is considerably¹⁸ more time-consuming because they have to be grown. Rather like one grows apples or grain.

So the robust¹⁹ and designable compounds may turn out to be just what's needed for a wide variety of jobs. Not least（尤其，相当重要） in the pharmaceutical²⁰ industries, where the need is massive for chemical compounds which can solve problems that no amount of designing could ever tweak（扭，拧） the natural ones to work on, which are unaffected by industrial processes, and to top it of, cheap to produce. #